2022•PubMedOpen access

Long non-coding RNA UCA1 promotes retinoblastoma progression by modulating the miR-124/c-myc axis.

Lan Wang, Mingxing Wu, Xiyuan Zhou

Abstract

. Mechanistically, UCA1 promoted c-myc expression through sponging miR-124. miR-124 inhibition or c-myc overexpression partially reversed the effects of UCA1 knockdown on retinoblastoma cells. Overall, lncRNA UCA1 may exert an oncogenic effect on retinoblastoma progression through the miR-124/c-myc axis, which might serve as a promising retinoblastoma treatment target.

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Key concepts: Retinoblastoma, Gene knockdown, Long non-coding RNA, Cancer research, Downregulation and upregulation, RNA, Biology, Apoptosis