2022Canadian Medical Association JournalOpen access

Treating acetaminophen overdose

Marco L.A. Sivilotti, Mark Yarema, David N. Juurlink

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Abstract

A billion doses of acetaminophen are taken safely each year, but 10000 people in Canada overdose on this medication annually. About one-third are hospitalized for treatment with the antidote, acetylcysteine, and 1%–2% die.[1][1] Most fatalities result from delayed presentation after deliberate

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A billion doses of acetaminophen are taken safely each year, but 10000 people in Canada overdose on this medication annually. About one-third are hospitalized for treatment with the antidote, acetylcysteine, and 1%–2% die.[1][1] Most fatalities result from delayed presentation after deliberate

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Available abstract

A billion doses of acetaminophen are taken safely each year, but 10000 people in Canada overdose on this medication annually. About one-third are hospitalized for treatment with the antidote, acetylcysteine, and 1%–2% die.[1][1] Most fatalities result from delayed presentation after deliberate

Key concepts: Acetylcysteine, Antidote, acetaminophen overdose, Acetaminophen, Medicine, Drug overdose, Presentation (obstetrics), Emergency medicine

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