Assessment of the antiulcer properties of Lawsonia inermis L. leaves and its nano-formulation against prolonged effect of acute ulcer in rats

Peptic ulcer syndrome (PUD) has been acknowledged as one of the most frequent causes of morbidity and mortality worldwide throughout the 20th and 21st centuries. Several reports indicated the ability of plant derived dosages as antiulcer agents. Many prior investigations have implied some biological activities of Lawsonia inermis L. The aim of this current investigation was to estimate the antiulcer capability of Lawsonia inermis L. leaves and its nano formulation against hazardous biochemical and histological changes in aspirin-induced ulcer rats. Methods divided into 6 groups (6 rats/group), Normal control (negative), Group (1) receiving dose of (200 g/kg) Lawsonia inermis L. for 8 weeks, Group (2) receiving (200 g/kg) nano Lawsonia inermis L. leaves for 8 weeks, Group (3) ulcer control group receiving a single dose (500 mg aspirin/kg rat body weight),groups 4& 5 receiving aspirin and either Lawsonia inermis L. leaves or nano Lawsonia inermis L. leaves for 8 weeks. Results: improvements in all the tested parameters as well as hepatic enzymes activities and some blood biochemical parameters. Conclusion Lawsonia inermis L.at the tested dose could prevent ulcer formation in the tested animals that may offer safe and low cost effective treatment for gastric ulcer.