2006•Methods and principles in medicinal chemistryRequires access
Physicochemistry
Dr. Dennis A. Smith, Dr. Han van de Waterbeemd, Dr. Don K. Walker
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Abstract
This chapter contains sections titled: Physicochemistry and Pharmacokinetics Partition and Distribution Coefficient as Measures of Lipophilicity Limitations on the Use of 1-Octanol Further Understanding of Log P Unravelling the Principal Contributions to Log P Hydrogen Bonding Molecular Size and Shape Alternative Lipophilicity Scales Different Solvent Systems Chromatographic Approaches Liposome Partitioning Computational Approaches to Lipophilicity Membrane Systems to Study Drug Behaviour Dissolution and Solubility Why Measure Solubility? Calculated Solubility Ionisation (pKa)