Spectrum of biopsy renal disease in central China: a nine-year retrospective study of 1929 cases

Abstract Objective To investigate the renal pathology and transitions of children who received a renal biopsy at the First Affiliated Hospital of Zhengzhou University between 2012 and 2020. Methods The clinical and pathological data of children with a renal biopsy were analyzed retrospectively. The changes in the distribution of pathological types were examined in age groups of 3 years (-1, -3, -6, -12, -16 years) and gender. Results 1928 children with renal biopsies were included in the analysis. The mean age of the children was 8.18±SD 3.40 years and the ratio of males to females was 1.71. The main pathological types of primary glomerular disease were minimal change disease (MCD) and IgA nephropathy, while the main pathological types of secondary glomerulonephritis were lupus nephritis and Henoch-Schonlein purpura (HSPN). The male to female ratio and age distribution between lupus nephritis and HSP were significantly different.