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Molecular Biology of the Renin-Angiotensin System

Nilesh J. Samani

Open publisher page 6 citations

Abstract

In the last decade, nucleic acid sequences coding for all three components of the renin-angiotensin cascade have been cloned. This has led to increased understanding of the trunscriptional and translationsl regulation of renin, angiotensinogen, and angiotensin-converting enzyme (ACE). This review discusses the impact of the availability of these clones in three clinically relevant areas—the role of the renin-angiolensin system in hypertension, the role of tissue renin-angiotensin systems, and the development of renin inhibitors.

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What this paper is about

In the last decade, nucleic acid sequences coding for all three components of the renin-angiotensin cascade have been cloned. This has led to increased understanding of the trunscriptional and translationsl regulation of renin, angiotensinogen, and angiotensin-converting enzyme (ACE). This review discusses the impact of the availability of these clones in three clinically relevant areas—the role of the renin-angiolensin system in hypertension, the role of tissue renin-angiotensin systems, and the development of renin inhibitors.

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OpenAlex reports 6 citations for this work. Citation counts describe recorded attention and do not establish research quality.

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Available abstract

In the last decade, nucleic acid sequences coding for all three components of the renin-angiotensin cascade have been cloned. This has led to increased understanding of the trunscriptional and translationsl regulation of renin, angiotensinogen, and angiotensin-converting enzyme (ACE). This review discusses the impact of the availability of these clones in three clinically relevant areas—the role of the renin-angiolensin system in hypertension, the role of tissue renin-angiotensin systems, and the development of renin inhibitors.

Key concepts: Renin–angiotensin system, Peptidyl-Dipeptidase A, Angiotensin II, Biology, Internal medicine, Endocrinology, Medicine, Blood pressure

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