1981•ACS symposium seriesRequires access
Hydrolysis of Adenosine 5′-Triphosphate
Seymour Meyerson, E. Kuhn, Fausto Ramírez, James F. Marecek
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Abstract
The key role played by adenosine 5'-triphosphate (ATP) in biophosphorus chemistry has prompted numerous investigations of its mechanism of hydrolysis( 1 - 6 ), but many questions remain unanswered(7). In principle the nonenzymetic hydrolysis of ATP can occur via four primary pathways: H 2 O + ATP(Pγ) ⇌ ADP + P i (1) H 2 O + ATP(Pβ) ⇌ P i + ADP (2) H 2 O + ATP(Pβ) ⇌ AMP + PP i (3) H 2 O + ATP(Pαa) ⇌ PP i + AMP (4) Further hydrolysis of the ADP can proceed via two different pathways: H 2 O + ADP(Pβ) ⇌ AMP + P i (5) H 2 O + ADP(Pα) ⇌ P i + AMP (6) A recent paper(8) reported a study of the hydrolysis of ATP in 0.01 M aqueous solutions at 70° C in the pH range 0-10. Representative values of the pseudo-first order rate constants are: (a) in 1 N HCl, k = 13.9 x 10 -2 min -1, t½ = 5 min; (b) in 0.1 N HCl,>