2022•European Journal of Medicinal ChemistryOpen access

Discovery of a novel and potent inhibitor with differential species-specific effects against NLRP3 and AIM2 inflammasome-dependent pyroptosis

Jiao Yan, Jinshan Nan, Bo Mu, Yun Zhang, Nenghua Zhou, Shunhua Yang, Shunhua Yang, Shanshan Zhang, Wan-Ting Lin, Falu Wang, Anjie Xia, Zhixing Cao, Pei Chen, Zhiling Pan, Guifeng Lin, Shulei Pan, Huachao Bin, Linli Li, Shengyong Yang, Shengyong Yang

Open full text 56 citations

Abstract

This record does not include an abstract. Use the full-text link above if available.

About this research paper

What this paper is about

An abstract is not available in the OpenAlex record for this paper.

Why it matters

OpenAlex reports 56 citations for this work. Citation counts describe recorded attention and do not establish research quality.

Key contribution

A contribution statement is not available in the OpenAlex record.

Method / approach

Method details are not available in the OpenAlex metadata.

Main findings

Findings are not separately available in the OpenAlex metadata.

Limitations

Limitations are not available in the OpenAlex metadata.

Applications

Application details are not available in the OpenAlex metadata.

Key concepts: Pyroptosis, Inflammasome, AIM2, Chemistry, Proinflammatory cytokine, Caspase 1, NLRC4, Programmed cell death