1989•Psychiatry and PsychobiologyRequires access
Monitoring of tricyclic antidepressant plasma levels and clinical response: a review of the literature. Part I.
Irismar Reis de Oliveira, Pedro Antônio Schmidt do Prado‐Lima, B Samuel-Lajeunesse
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Abstract
Summary Part I of this paper presents a comprehensive review of plasma level monitoring of tricyclic antidepressants (TCAs) and their relationship to clinical response to antidepressant therapy. Imipramine, nortriptyline, amitriptyline, clomipramine and desipramine are the most widely studied TCAs in this regard. Typical therapeutic plasma concentration ranges are suggested for some of these agents, although a consensus is lacking.