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Ribosome-Inactivating Proteins
Fiorenzo Stirpe
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Abstract
The designation of ribosome-inactivating proteins (RIPs; reviews in refs. 1 – 4 ) has been applied to plant proteins that enzymatically damage ribosomes in a catalytic manner, thus inhibiting protein synthesis (Table 1). The first identified RIPs were two potent toxins, known for more than a century: ricin, from the seeds of Ricinus communis , and abrin, from the seeds of Abrus precatorius .