ScholarLens Back to search
2004•Science s STKERequires access

Protecting Damaged Axons

Author information unavailable

Open publisher page 0 citations

Abstract

Degeneration of axons that have been severed from their neuronal cell bodies can follow a specific course of progressive fragmentation called Wallerian degeneration. Various neurodegenerative diseases are also characterized by axonal degeneration. Araki et al. (see the Perspective by Bedalov and Simon) provide new insight into what directs the course of organized axonal degeneration. Analysis of a fusion protein resulting from a mutation that slows axon degeneration implicates the nicotinamide adenine dinucleotide biosynthetic pathway in this type of axonal degeneration. T. Araki, Y. Sasaki, J. Milbrandt, Increased nuclear NAD biosynthesis and SIRT1 activation prevent axonal degeneration. Science 305 , 1010-1013 (2004). [Abstract] [Full Text] A. Bedalov, J. A. Simon, NAD to the rescue. Science 305 , 954-955 (2004). [Summary] [Full Text]

About this research paper

What this paper is about

Degeneration of axons that have been severed from their neuronal cell bodies can follow a specific course of progressive fragmentation called Wallerian degeneration. Various neurodegenerative diseases are also characterized by axonal degeneration. Araki et al. (see the Perspective by Bedalov and Simon) provide new insight into what directs the course of organized axonal degeneration. Analysis of a fusion protein resulting from a mutation that slows axon degeneration implicates the nicotinamide adenine dinucleotide biosynthetic pathway in this type of axonal degeneration. T. Araki, Y. Sasaki, J. Milbrandt, Increased nuclear NAD biosynthesis and SIRT1 activation prevent axonal degeneration. Science 305 , 1010-1013 (2004). [Abstract] [Full Text] A. Bedalov, J. A. Simon, NAD to the rescue. Science 305 , 954-955 (2004). [Summary] [Full Text]

Why it matters

A significance statement is not available in the OpenAlex record.

Key contribution

A contribution statement is not available in the OpenAlex record.

Method / approach

Method details are not available in the OpenAlex metadata.

Main findings

Findings are not separately available in the OpenAlex metadata.

Limitations

Limitations are not available in the OpenAlex metadata.

Applications

Application details are not available in the OpenAlex metadata.

Available abstract

Degeneration of axons that have been severed from their neuronal cell bodies can follow a specific course of progressive fragmentation called Wallerian degeneration. Various neurodegenerative diseases are also characterized by axonal degeneration. Araki et al. (see the Perspective by Bedalov and Simon) provide new insight into what directs the course of organized axonal degeneration. Analysis of a fusion protein resulting from a mutation that slows axon degeneration implicates the nicotinamide adenine dinucleotide biosynthetic pathway in this type of axonal degeneration. T. Araki, Y. Sasaki, J. Milbrandt, Increased nuclear NAD biosynthesis and SIRT1 activation prevent axonal degeneration. Science 305 , 1010-1013 (2004). [Abstract] [Full Text] A. Bedalov, J. A. Simon, NAD to the rescue. Science 305 , 954-955 (2004). [Summary] [Full Text]

Key concepts: Wallerian degeneration, Degeneration (medical), Axonal degeneration, Neuronal degeneration, NAD+ kinase, Axon, Neurodegeneration, Nicotinamide adenine dinucleotide

Related papers

Related paper 1Related paper 2Related paper 3
Back to paper searchBrowse research topicsOriginal source
Protecting Damaged Axons — Research Paper | ScholarLens