2022•Stem Cell ResearchOpen access

Establishment of SIAISi018-A, an induced pluripotent stem cell (iPSC) line from a healthy 45-year-old Chinese Han

Yi Zhang, Jiajun Shou, Wentao Gu, Weihao Di, Jian Zhao, Ying Wang, Shixin Gu

Abstract

A 45-year-old Han Male from China contributed peripheral blood mononuclear cells induced by reprogramming human OKSM transcription factors (OCT3/4, KLF4 SOX2 and C-MYC) with a non-integrated additional vector system. Immunological markers confirmed the pluripotent nature of IPSC. Spontaneous tridermal differentiation confirmed the differentiation ability of IPSC with normal karyotype.

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Available abstract

Key concepts: Induced pluripotent stem cell, SOX2, Reprogramming, Biology, KLF4, Peripheral blood mononuclear cell, Karyotype, Stem cell