2008Textbook of GastroenterologyRequires access

Hepatic Regeneration

George K. Michalopoulos, Marie C. DeFrances

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Abstract

This chapter contains sections titled: Why does the liver need to regenerate? Experimental models and clinical settings Cellular kinetics during liver regeneration after partial hepatectomy Functional and structural changes in liver histology during regeneration General functional aspects of cell signaling during liver regeneration Extracellular signals leading liver into regeneration Intracellular events occurring during regeneration Extracellular matrix changes and angiogenesis Paracrine signaling interactions between different cell types during liver regeneration What starts and ends liver regeneration: a semispeculative view Alternative pathways to liver regeneration: oval cells and stem cells Clinical aspects of liver regeneration: cirrhosis and fulminant hepatitis Augmentative hepatomegaly Conclusions References

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What this paper is about

This chapter contains sections titled: Why does the liver need to regenerate? Experimental models and clinical settings Cellular kinetics during liver regeneration after partial hepatectomy Functional and structural changes in liver histology during regeneration General functional aspects of cell signaling during liver regeneration Extracellular signals leading liver into regeneration Intracellular events occurring during regeneration Extracellular matrix changes and angiogenesis Paracrine signaling interactions between different cell types during liver regeneration What starts and ends liver regeneration: a semispeculative view Alternative pathways to liver regeneration: oval cells and stem cells Clinical aspects of liver regeneration: cirrhosis and fulminant hepatitis Augmentative hepatomegaly Conclusions References

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Available abstract

This chapter contains sections titled: Why does the liver need to regenerate? Experimental models and clinical settings Cellular kinetics during liver regeneration after partial hepatectomy Functional and structural changes in liver histology during regeneration General functional aspects of cell signaling during liver regeneration Extracellular signals leading liver into regeneration Intracellular events occurring during regeneration Extracellular matrix changes and angiogenesis Paracrine signaling interactions between different cell types during liver regeneration What starts and ends liver regeneration: a semispeculative view Alternative pathways to liver regeneration: oval cells and stem cells Clinical aspects of liver regeneration: cirrhosis and fulminant hepatitis Augmentative hepatomegaly Conclusions References

Key concepts: Regeneration (biology), Liver regeneration, Paracrine signalling, Cell biology, Biology, Extracellular matrix, Extracellular, Pathology

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