[The role and research progress of IL-17 in the pathogenesis of osteoarthritis].

Osteoarthritis (OA) is one of the most common chronic diseases with complex and varied pathogenic factors. Inflammatory response of diseased joint aggravates the degeneration of cartilage and the destruction of subchondral bone. Interleukin 17 (IL-17) is a multifunctional pro-inflammatory cytokine, which plays a significant role in the inflammation of synovium, the degeneration of cartilage, and the destruction of subchondral bone. This article has reviewed the role of IL-17 in the pathophysiological pathogenesis of OA on the levels of molecules, cells, and tissues, and the progress of targeted therapy based on IL-17 for OA.