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2021•Biochemical Society TransactionsRequires access

The role of caspases as executioners of apoptosis

Sharad Kumar, Loretta Dorstyn, Yoon Lim

Open publisher page 67 citations

Abstract

Caspases are a family of cysteine aspartyl proteases mostly involved in the execution of apoptotic cell death and in regulating inflammation. This article focuses primarily on the evolutionarily conserved function of caspases in apoptosis. We summarise which caspases are involved in apoptosis, how they are activated and regulated, and what substrates they target for cleavage to orchestrate programmed cell death by apoptosis.

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What this paper is about

Caspases are a family of cysteine aspartyl proteases mostly involved in the execution of apoptotic cell death and in regulating inflammation. This article focuses primarily on the evolutionarily conserved function of caspases in apoptosis. We summarise which caspases are involved in apoptosis, how they are activated and regulated, and what substrates they target for cleavage to orchestrate programmed cell death by apoptosis.

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OpenAlex reports 67 citations for this work. Citation counts describe recorded attention and do not establish research quality.

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Available abstract

Caspases are a family of cysteine aspartyl proteases mostly involved in the execution of apoptotic cell death and in regulating inflammation. This article focuses primarily on the evolutionarily conserved function of caspases in apoptosis. We summarise which caspases are involved in apoptosis, how they are activated and regulated, and what substrates they target for cleavage to orchestrate programmed cell death by apoptosis.

Key concepts: Caspase, Apoptosis, Proteases, Intrinsic apoptosis, Cell biology, Programmed cell death, Caspase 2, XIAP

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