2011•Vestnik of Lobachevsky State University of Nizhni Novgorod Series Social SciencesRequires access
Локализация белка p53 во фракциях хроматина и препаратах ядерного матрикса клеток различных типов
Лапшина Мария Александровна, Пархоменко Игорь Иванович, Терентьев Алексей Алексеевич
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Abstract
The tumor suppressor p53 can associate with the nuclear matrix. The fractionation of nuclei and purification of nuclear matrix from cells of different types have been carried out and p53 protein content in fractions of the cell nucleus has been studied. It is shown that localization of p53 in chromatin fractions and the degree of its association with the nuclear matrix depend on the type of cells.