STUDIES ON BIOLOGY OF THE INCLUSION BODIES IN EHRLICH ASCITIC TUMOR CELLS WHICH WERE INFECTED WITH ECTROMELIA VIRUS

The morphological studies were extended further mainly by the electron microscopy of the ultra-thin sectioned specimens and revealed the presence of two different types of inclusion bodies which were observed inside of the Ehrlich ascitic tumor cells infected with ectromelia virus, especially at the terminal stages of transplanted animals.Two strains of ectromelia virus were distinctly differentiated each other by the mode of viral multiplication within their blue staining inclusion bodies.In the case of A strain of the virus, a close co-relationship was evident between the electron density of the ground substance of the inclusion bodies and the number of the viral particles within them. The destructive picture of the inclusion bodies were never observed along the whole course of the infection.On the other hand, B strain of the virus did not show any morphological evidence to invade the blue staining inclusion bodies which were formed up independently from the viral particles.