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Lichen planus induced by interferon-alpha-2a therapy for chronic active hepatitis C.

T Barreca, G Corsini, Roberto Franceschini, Claudio Gambini, A Garibaldi, E Rolandi

Abstract

OBJECTIVE: To report the development of hepatitis C virus (HCV)-positive chronic active hepatitis with lichen planus in a patient during interferon treatment. DESIGN: Case report and literature review. PATIENT: A 64-year-old anti-HCV and HCV-RNA-positive woman. INTERVENTIONS: The patient received interferon-alpha-2a treatment for histologically proven chronic active hepatitis. RESULTS: Four months after the start of treatment the patient developed multiple cutaneous lesions on her hands, feet and back. A skin biopsy led to the diagnosis of lichen planus. The withdrawal of interferon was followed by a marked improvement in the cutaneous lesions, but not complete regression. CONCLUSION: This case shows that HCV-positive patients with chronic active hepatitis may develop lichen planus during interferon therapy.

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Key concepts: Medicine, Interferon, Alpha interferon, Hepatitis C virus, Chronic hepatitis, Interferon alfa, Hepatitis C, Biopsy