2004•Wuhan University Journal of Natural SciencesRequires access
Analysis of gene expression profile in lung adenosquamous carcinoma using cDNA microarray
Fei Ying Yang, Jiong Yang, Man Jiang, Ye Bo, Yuxia Zhang, Honglei Chen, Xia Dong, Mingqiu Liu
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Abstract
Gene expression profile of the lung adenosquamous carcinoma was characterized by using cDNA microarray chip containing 4 096 human genes. Among target genes, 508 differentially expressed genes were identified in adenosquamous carcinoma of the lung, 232 genes were overexpressed and 276 genes were underexpressed. Among them, 92 genes are cell signals transduction genes, 34 genes are proto-oncogenes and tumor suppressor genes or cell cycle related genes or cell apoptosis related genes, 29 genes are cell skeleton genes, 28 genes are DNA synthesis, repair and recombination genes, 12 genes are DNA binding and transcription genes. These genes may be associated with the occurence and development of adenosquamous carinome of the lung.