2007•Unpublished venueRequires access
In vivo Evaluation of the Mutagenic Potential of Estragole and Eugenol Chemotypes of Ocimum selloi Benth. Essential Oil
Josiane Padilha de Paula, Paulo Vítor Farago, João Luiz Coelho Ribas, Gisele Mara, S. Spinardi, Patricia M. Döll, Roberto Ferreira Artoni, Sônia Faria Zawadzki
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Abstract
SUMMARY. The aim of this work was to investigate the chemical composition and mutagenicity of the O. selloi essential oils native from the South of Brazil. The essential oil designated as chemotype A showed a total of 10 components, which constitute more than 99% of the volatile fraction. The major chemicals were methyl chavicol or estragole (46.33%), trans-anethole (31.20%) and germacrene D (6.37%). The chemotype of O. selloi called sample B was constituted by only 4 detected components as the most abundant compounds, with more than 99% of the composition of the essential oil characterized. The major constituents were methyl eugenol (45.17%), trans-caryophyllene (43.52%) and isoaromadendrene (4.83%). The results obtained in the in vivo evaluation of mutagenicity indicated that none of chemotype studied presents mutagenic activity. These results support existing information about the low toxicological risk in the O. selloi use as a traditional medicine.