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The antioxidant activity of ethanol extracts from Phellinus baumii and their protective effects against oxidative damage of nerve cells.

Hu JinXia, Yang Yan, Zhang JinSong, Qingjiu Tang, Yanfang Liu, Ruixia Hao, Na Feng

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Abstract

The antioxidant activity of ethanol extracts of eight kinds of Phellinus baumii fruiting body and their protective effects against oxidative damage of nerve cells were investigated by chemiluminometry and a model of PC12 oxidative damage by H2O2.The results showed that all the extracts had a good antioxidant activity.The extract from PB-10 had the greatest activity and its IC50 was 3.76 μgmL for superoxide anion and 4.24 μgmL for hydrogen peroxide.All the extracts at the concentration of 10 μgmL had good protective and repair effects on PC12 cells damaged by H2O2,and the extract from PB-10 could reach(72.5±0.3)% repair rate at the concentration of 10 μgmL and up to(90.7±3.6)% at 150 μgmL.There were positive correlations between the antioxidant activities and protective effects of all the extracts and the flavone concentrations of them.

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What this paper is about

The antioxidant activity of ethanol extracts of eight kinds of Phellinus baumii fruiting body and their protective effects against oxidative damage of nerve cells were investigated by chemiluminometry and a model of PC12 oxidative damage by H2O2.The results showed that all the extracts had a good antioxidant activity.The extract from PB-10 had the greatest activity and its IC50 was 3.76 μgmL for superoxide anion and 4.24 μgmL for hydrogen peroxide.All the extracts at the concentration of 10 μgmL had good protective and repair effects on PC12 cells damaged by H2O2,and the extract from PB-10 could reach(72.5±0.3)% repair rate at the concentration of 10 μgmL and up to(90.7±3.6)% at 150 μgmL.There were positive correlations between the antioxidant activities and protective effects of all the extracts and the flavone concentrations of them.

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Available abstract

The antioxidant activity of ethanol extracts of eight kinds of Phellinus baumii fruiting body and their protective effects against oxidative damage of nerve cells were investigated by chemiluminometry and a model of PC12 oxidative damage by H2O2.The results showed that all the extracts had a good antioxidant activity.The extract from PB-10 had the greatest activity and its IC50 was 3.76 μgmL for superoxide anion and 4.24 μgmL for hydrogen peroxide.All the extracts at the concentration of 10 μgmL had good protective and repair effects on PC12 cells damaged by H2O2,and the extract from PB-10 could reach(72.5±0.3)% repair rate at the concentration of 10 μgmL and up to(90.7±3.6)% at 150 μgmL.There were positive correlations between the antioxidant activities and protective effects of all the extracts and the flavone concentrations of them.

Key concepts: Antioxidant, Chemistry, Hydrogen peroxide, Ethanol, Superoxide, Oxidative damage, Oxidative phosphorylation, Pharmacology

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The antioxidant activity of ethanol extracts from Phellinus baumii and their protective effects against oxidative damage of nerve cells. — Research Paper | ScholarLens