1989•American Journal of PsychiatryRequires access

Open trial of fluoxetine in obsessive-compulsive disorder

M A Jenike, Lita Buttolph, Lee Baer, Joseph N. Ricciardi, Anthony Holland

Abstract

A 12-week open trial of fluoxetine in 61 obsessive-compulsive disorder patients significantly improved depressive and obsessive-compulsive symptoms. Baseline depression scores were not related to improvement on two obsessive-compulsive scales. The results reinforce the hypothesis of serotonergic abnormalities in obsessive-compulsive disorder.

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Key concepts: Fluoxetine, Obsessive compulsive, Psychology, Psychiatry, Clinical psychology, Psychotherapist, Medicine, Internal medicine