Histopathological changes in broiler chickens fed aflatoxin and cyclopiazonic acid.

Experimental mycotoxicoses was induced into broiler chickens by feeding 1 ppm afl atoxin (AF) and 20 ppm cyclopiazonic acid (CPA) from 0 to 28 days of age to evaluate the gross and histopathological changes.Grossly, AF and AF-CPA fed birds showed enlargement, yellowish discoloration of the liver while the CPA fed birds showed enlargement and congestion.The CPA and AF-CPA fed birds showed thickening of crop and necrosis and thickening of proventricular mucosa.Histopathologically, degenerative and necrotic changes were observed in the liver, kidneys, intestine, pancreas, heart, pectoral muscle, spleen and bursa of Fabricius of all toxin fed birds.Besides, hyperplastic changes were also observed in the crop, proventriculus and gizzard in the CPA fed birds.The lesions were more marked in the AF-CPA group.The study revealed that AF and CPA in combination could act cumulatively and adversely affect the health of broiler chicken.