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1999•Journal of Pharmacy Practice and ResearchOpen access

Raised INR with Concurrent Warfarin and Azithromycin

Michael D. Wiese, David G Cosh

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Abstract

Warfarin interacts with various antibiotics with varying clinical significance. Two patients who were stable on warfarin had clinically significant increases in INRs when azithromycin was introduced. In one, the increased INR was associated with asymptomatic alterations in liver function tests. We believe close monitoring ofINR is warranted when patients are treated concurrently with warfarin and azithromycin.

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What this paper is about

Warfarin interacts with various antibiotics with varying clinical significance. Two patients who were stable on warfarin had clinically significant increases in INRs when azithromycin was introduced. In one, the increased INR was associated with asymptomatic alterations in liver function tests. We believe close monitoring ofINR is warranted when patients are treated concurrently with warfarin and azithromycin.

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OpenAlex reports 8 citations for this work. Citation counts describe recorded attention and do not establish research quality.

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Available abstract

Warfarin interacts with various antibiotics with varying clinical significance. Two patients who were stable on warfarin had clinically significant increases in INRs when azithromycin was introduced. In one, the increased INR was associated with asymptomatic alterations in liver function tests. We believe close monitoring ofINR is warranted when patients are treated concurrently with warfarin and azithromycin.

Key concepts: Azithromycin, Warfarin, Medicine, Asymptomatic, Antibiotics, Internal medicine, Clinical significance, Atrial fibrillation

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