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Multiple Myeloma and Related Disorders

Robert A. Kyle

Open publisher page 18 citations

Abstract

Multiple myeloma is characterized by the neoplastic proliferation of a single clone of plasma cells engaged in the production of a monoclonal immunoglobulin. Proliferation of the plasma cells in the bone marrow produces skeletal destruction that results in bone pain and fractures. The excessive production of the monoclonal protein (M-protein) can lead to renal failure, recurrent bacterial infections, or hyperviscosity syndrome. Anemia and hypercalcemia are other important features.

About this research paper

What this paper is about

Multiple myeloma is characterized by the neoplastic proliferation of a single clone of plasma cells engaged in the production of a monoclonal immunoglobulin. Proliferation of the plasma cells in the bone marrow produces skeletal destruction that results in bone pain and fractures. The excessive production of the monoclonal protein (M-protein) can lead to renal failure, recurrent bacterial infections, or hyperviscosity syndrome. Anemia and hypercalcemia are other important features.

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OpenAlex reports 18 citations for this work. Citation counts describe recorded attention and do not establish research quality.

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Available abstract

Multiple myeloma is characterized by the neoplastic proliferation of a single clone of plasma cells engaged in the production of a monoclonal immunoglobulin. Proliferation of the plasma cells in the bone marrow produces skeletal destruction that results in bone pain and fractures. The excessive production of the monoclonal protein (M-protein) can lead to renal failure, recurrent bacterial infections, or hyperviscosity syndrome. Anemia and hypercalcemia are other important features.

Key concepts: Hyperviscosity syndrome, Multiple myeloma, clone (Java method), Bone marrow, Monoclonal, Hyperviscosity, Medicine, Myeloma protein

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