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2021•Unpublished venueRequires access

A magnetic field enhanced microfluidic device for precise particle separation

Yujie Zhou, Shu Zhu, Nan Xiang, Zhonghua Ni

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Abstract

In this paper, we present a magnetic field enhanced microfluidic device fabricated based on MEMS technology for precise particle separation. The use of high permeability channels in our device intensifies the magnetic field gradient in the magnetic separation channel, and the increased magnetic fields can improve the separation efficiency of the magnetic particles. Besides, deflecting the magnetic particles to the middle of the channel can prevent blockage. To verify the feasibility of our device, simulation and particle experiments are conducted. A recovery ratio as high as 92.2% was achieved successfully. Therefore, our device is promising for precise cell separation in the following biochemical experiments.

About this research paper

What this paper is about

In this paper, we present a magnetic field enhanced microfluidic device fabricated based on MEMS technology for precise particle separation. The use of high permeability channels in our device intensifies the magnetic field gradient in the magnetic separation channel, and the increased magnetic fields can improve the separation efficiency of the magnetic particles. Besides, deflecting the magnetic particles to the middle of the channel can prevent blockage. To verify the feasibility of our device, simulation and particle experiments are conducted. A recovery ratio as high as 92.2% was achieved successfully. Therefore, our device is promising for precise cell separation in the following biochemical experiments.

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Available abstract

In this paper, we present a magnetic field enhanced microfluidic device fabricated based on MEMS technology for precise particle separation. The use of high permeability channels in our device intensifies the magnetic field gradient in the magnetic separation channel, and the increased magnetic fields can improve the separation efficiency of the magnetic particles. Besides, deflecting the magnetic particles to the middle of the channel can prevent blockage. To verify the feasibility of our device, simulation and particle experiments are conducted. A recovery ratio as high as 92.2% was achieved successfully. Therefore, our device is promising for precise cell separation in the following biochemical experiments.

Key concepts: Microfluidics, Magnetic separation, Magnetic field, Materials science, Magnetic nanoparticles, Particle (ecology), Permeability (electromagnetism), Microelectromechanical systems

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