2021•American Journal of Physiology-Gastrointestinal and Liver PhysiologyOpen access
Tissue-specific mechanisms of bile acid homeostasis and activation of FXR-FGF19 signaling in preterm and term neonatal pigs
Caitlin E. Vonderohe, Gregory J. Guthrie, Barbara J. Stoll, Shaji K. Chacko, Harry Dale Dawson, Douglas G. Burrin
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Abstract
Our results show that the lower hepatic bile acid synthesis and ileum FXR-FGF19 pathway responsiveness to bile acids contribute to low-circulating FGF19 in preterm compared with term neonatal pigs. The molecular mechanism explaining immature or low-ileum FXR-FGF19 signaling may be linked to developmental patterning effects of GATA-4.