2021•Experimental DermatologyOpen access

Ketoconazole beyond antifungal activity: Bioinformatics‐based hypothesis on lipid metabolism in dandruff and seborrheic dermatitis

Vinicius Goularte‐Silva, Luciana Campos Paulino

Abstract

The role of Malassezia yeasts in dandruff and seborrheic dermatitis is unclear; however, antifungal therapy with ketoconazole is commonly used. We propose that ketoconazole shifts skin lipid profile, affects Malassezia lipid metabolism and favours biotin-producing bacteria. Biotin regulates inflammatory response and cell proliferation, contributing to symptom improvement.

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Available abstract

Key concepts: Ketoconazole, Seborrheic dermatitis, Dandruff, Malassezia, Seborrhoeic dermatitis, Antifungal, Biology, Lipid metabolism