Do collaterals visualized on coronary angiography impact left ventricle ejection fraction among Asian Indians presenting with acute coronary syndrome? The Deucalion Study

Background The coronary collaterals have been ascribed as a potential alternative source of myocardial perfusion to the extent that some suggest it as a “natural bypass”! We proposed to evaluate the impact of the extent of collaterals on left ventricle ejection fraction among Asian Indians presenting with acute coronary syndrome. Methods This was a retrospective, all-comers study performed on consecutive 3614 patients presenting with the acute coronary syndrome. Angiograms were evaluated for collaterals graded according to Rentrop’s classification among group A (grades 0 and 1) and group B (grades 2 and 3) collaterals. Results Patients were matched for traditional cardiovascular risk factors in groups A and B as well as for ST elevation myocardial infarction and non-ST elevation myocardial infarction subgroups in both the groups. Grades 2 and 3 collaterals were significantly ( P = 0.04) higher in patients with non-ST elevation myocardial infarction—266/1319 (20.17%), as compared to ST elevation myocardial infarction—group 400/2295 (17.43%). Left ventricle ejection fraction on presentation was better preserved in group A as compared to group B in those with double-vessel disease and triple-vessel disease patients with non-ST elevation myocardial infarction, whereas it was better in single-vessel disease and triple-vessel disease patients with ST elevation myocardial infarction. The inverse correlation ( r = −0.111, P = 0.000) existed between left ventricle ejection fraction and grades of collaterals. Conclusion Patients with the single-vessel disease were more likely to have poor coronary collateral as compared to double-vessel disease/triple-vessel disease. Despite higher grade coronary collateral among Asian Indians presenting with acute coronary syndrome, both non-ST elevation myocardial infarction and ST elevation myocardial infarction patients with triple-vessel disease had significantly lower left ventricle ejection fraction. This paradoxically brings out worse left ventricle ejection fraction on presentation in those with double-vessel disease and triple-vessel disease with ST elevation myocardial infarction and single-vessel disease and triple-vessel disease with ST elevation myocardial infarction despite higher grade of coronary collateral representing as “Asian Indian Paradox” in our cohort.