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2021•Canadian Medical Association JournalOpen access

Ketamine for the treatment of acute pain

William K. Silverstein, David Nelson Juurlink, Jonathan S. Zipursky

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Abstract

Ketamine is a phencyclidine (PCP) derivative that exerts its effects primarily through N -methyl-d-aspartate receptor inhibition.[1][1] At low doses (0.1–0.3 mg/kg), ketamine produces mainly analgesia. Dissociative anesthesia and psychomimetic effects occur with higher doses (≥ 1.0 mg/kg). Low-

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What this paper is about

Ketamine is a phencyclidine (PCP) derivative that exerts its effects primarily through N -methyl-d-aspartate receptor inhibition.[1][1] At low doses (0.1–0.3 mg/kg), ketamine produces mainly analgesia. Dissociative anesthesia and psychomimetic effects occur with higher doses (≥ 1.0 mg/kg). Low-

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Available abstract

Ketamine is a phencyclidine (PCP) derivative that exerts its effects primarily through N -methyl-d-aspartate receptor inhibition.[1][1] At low doses (0.1–0.3 mg/kg), ketamine produces mainly analgesia. Dissociative anesthesia and psychomimetic effects occur with higher doses (≥ 1.0 mg/kg). Low-

Key concepts: Ketamine, Phencyclidine, Dissociative, Anesthesia, Medicine, Pharmacology, NMDA receptor, Receptor

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