Interfering with Bacterial Signalling Mechanisms as a Novel Strategy to Control Diseases – Aquaculture as a Case Study

Bacterial pathogens are quickly developing resistance to all known antibiotics. As a result, antibiotic treatments become ineffective, and diseases caused by antibiotic-resistant bacteria are currently a major cause of death worldwide. Bacterial cell-to-cell signalling mechanisms (quorum sensing) control several phenotypes that are required by pathogens to infect their host. Therefore, interfering with these mechanisms is now intensively studied as a novel strategy to control bacterial diseases.