ScholarLens Back to search
2021•Science ImmunologyOpen access

NLRP3 inflammasome activation triggers gasdermin D–independent inflammation

Chun Wang, Tong Yang, Jianqiu Xiao, Canxin Xu, Yael Alippe, Kai Sun, Thirumala‐Devi Kanneganti, Joseph B. Monahan, Yousef Abu‐Amer, Judy Lieberman, Gabriel Mbalaviele

Open full text 315 citations

Abstract

mice. Thus, NLRP3 inflammasome activation overwhelms the protection afforded by GSDMD deficiency, rewiring signaling cascades through mechanisms that include GSDME to propagate inflammation.

About this research paper

What this paper is about

mice. Thus, NLRP3 inflammasome activation overwhelms the protection afforded by GSDMD deficiency, rewiring signaling cascades through mechanisms that include GSDME to propagate inflammation.

Why it matters

OpenAlex reports 315 citations for this work. Citation counts describe recorded attention and do not establish research quality.

Key contribution

A contribution statement is not available in the OpenAlex record.

Method / approach

Method details are not available in the OpenAlex metadata.

Main findings

Findings are not separately available in the OpenAlex metadata.

Limitations

Limitations are not available in the OpenAlex metadata.

Applications

Application details are not available in the OpenAlex metadata.

Available abstract

mice. Thus, NLRP3 inflammasome activation overwhelms the protection afforded by GSDMD deficiency, rewiring signaling cascades through mechanisms that include GSDME to propagate inflammation.

Key concepts: Inflammasome, Pyroptosis, AIM2, Inflammation, Caspase 1, Secretion, Cell biology, Proinflammatory cytokine

Related papers

Related paper 1Related paper 2Related paper 3
Back to paper searchBrowse research topicsOriginal source
NLRP3 inflammasome activation triggers gasdermin D–independent inflammation — Research Paper | ScholarLens