Review on the Endoplasmic Reticulum Stress and Related Diseases

The endoplasmic reticulum is one of the most important organelles in eukaryotic cells, it serves lots of functions. It is a site for protein synthesis as well as modification and folding. The accumulation of unfolded proteins in the endoplasmic reticulum and calcium instability can trigger endoplasmic reticulum stress, which can be corrected by unfolded protein response. Excessive endoplasmic reticulum stress or abnormal endoplasmic reticulum stress mechanism will lead to cell damage and death. Recent studies have found that the disease of cancer, inflammation, osteoporosis and neurodegeneration is related to abnormal endoplasmic reticulum stress. Taking endoplasmic reticulum stress as a breakthrough point to study the pathogenesis of various diseases will greatly benefit the better treatment of these diseases and promote the development of medical technology. This article reviews some articles published in recent years and summarizes the relationship between endoplasmic reticulum stress and disease, and its possible mechanism.