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Human placental alkaline phosphatase electrophoretic alleles: quantitative studies.

P. Lucarelli, R. Scacchi, Rosa Maria Corbo, Alberto Benincasa, R. Palmarino

Abstract

Human placental alkaline phosphatase (ALP) activity has been determined in specimens obtained from 562 Italian subjects. The mean activities of the three common homozygotes (Pl 2 = 4.70 +/- 0.24, Pl 1 = 4.09 +/- 0.08, and Pl 3 = 2.15 +/- 0.71 mumol of p-nitrophenol produced) were significantly different. The differences among the various allelic forms account for 10% of the total quantitative variation of the human placental alkaline phosphatase.

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Key concepts: Alkaline phosphatase, Placental alkaline phosphatase, Allele, Biology, Allele frequency, Phosphatase, Phosphoric monoester hydrolases, Genetics