PERBANDINGAN EFEKTIVITAS AMLODIPINE DAN RAMIPRIL TERHADAP PENURUNAN TEKANAN DARAHPASIEN HIPERTENSI DI RSUD PROF. DR. MARGONO SOEKARJOMA

Burden disease of hypertension globally was 4,5 % (64 million patients with life disability-adjusted / DALYS). Prevalence of Hypertension in Indonesia was about 31,7% with age 18 years above. RSUD Margono Soekarjo as one of the biggest hospitals in Central Java specified therapy standard for hypertension by using drug of amlodipine or ramipril. The aim of this research was to determine comparison of effectiveness between amlodipine and rampiril in order to know the best approach of therapy in curing hypertension. Amlodipine was new generation of antagonist calcium with high selectivity and the bioavailibility 65-90 % so that it worked during 24 hours. Ramipril,Angiotensin Converting Enzym Inhibitor (ACEI), was effective as monotherapy. This research was kohort level to measure the reducing of blood pressure before and after given one of the drugs during 20 days. Statistic Analysis was Chi-Square. The amount of found sampel in RSUD Margono Soekarjo was 85 sample, only 70 sample (83.6 %) can be fulfilled inclusion and exclusion criterion so the sample was 70 sample with each amount 35 with medications of amlodipine and ramipril.The result, there was no difference between amlodipine and ramipril in reducing blood pressure during 20 days (p=0.329. ARR 11,5%)