2014•Unpublished venueRequires access
원저 : 음곡(陰谷) 백복령(白茯령)약침이 Lipopolysaccharide로 유도된 흰쥐의 염증성 신(腎) 손상에 미치는 영향
김민식, 김병수, 임윤경
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Abstract
Objectives : The purpose of this study is evaluating the effect of Hoelen Herbal-acupuncture (HO-HA) at KI10(Umgok) on Lipopolysaccharide(LPS) induced nephritis in rats Methods : The experimental rats were assigned to four groups; normal, LPS, saline, HO-HA groups. LPS(2 ㎎/㎏) was administered to the rats in LPS, saline and HO-HA groups to induce acute inflammatory kidney damage. Saline injection and HO-HA were administered at KI10 three times a week. Blood samples were taken from the rats for analysis of white blood cell(WBC), neutrophil, blood urea nitrogen(BUN), creatinine TNF-α, CINC-1. Urine samples were taken from the rats for analysis of urinal volume, creatinine and total protein. The kidney samples were taken from the rats for analysis of renal myeloperoxIdase(MPO). Results : HO-HA suppressed the increases of WBC and neutrophils in blood, BUN, creatinine, TNF-α and CINC-1 in serum, and MPO in kidney of LPS-stimulated rats. In addition, HO-HA inhibited the decrease of urinary volume in LPS-stimulated rats. Conclusions : HO-HA has therapeutic effects on LPS-induced inflammatory kidney damage in rats. Further studies may be needed for clinical use of HO-HA.