Immune suppression reversal of the spleen: a promising strategy for improving the survival rate of sepsis in rats.

T cell percentage in the peripheral blood could be reversed in splenectomy-treated rats. Splenectomy greatly decreased the number of white blood cells, lymphocytes, monocytes, neutrophils, and serum concentration of TNF-α and IL-10 after CLP. Moreover, splenectomy alleviated pathologic damage to the liver and lungs and weakened expression of CD163. These novel findings demonstrate that immune disorders of the spleen are important pathogenic factors during the course of severe sepsis. Splenectomy could alleviate apoptosis and reduction of lymphocytes induced by sepsis, and lower the level of inflammation in the body. Reversing the immune suppression of the spleen may be a novel strategy to improve sepsis survival.