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2021•Research Journal of Pharmacy and TechnologyRequires access

Analysis of Lipid profile and Atherogenic index (AIP) in dyslipidemia rats given Ipomea batatas tuber extract (IBTE)

Ni Kadek Warditiani, Ni Made Widi Astuti, Pande Made Nova Armita Sari, Dewa Ayu Swastini, I Made Agus Gelgel Wirasuta

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Abstract

To evaluate the effect of Ipomea batatas tuber extract (IBTE) on blood lipid profile and atherogenic index in plasma (AIP) of dyslipidemia rats. First, IBTE was extracted by methanol. Fat-rich diets was given for 30 days to induce dyslipidemia in rats. Then, IBTE was given to dyslipidemia rats for 21 days. Lipid profiles in the form of total cholesterol (TC), triglycerides (TG), low density lipoprotein-cholesterol (LDL-C), high lipoprotein-cholesterol (HDL-C) and AIP in rats were measured and analyzed. The results showed that administration of IBTE 150, 300 and 600mg/kg BW was able to improve the blood lipid profile of dyslipidemia rats, where there was a decrease in levels of TC, TG and LDL-C, and an increase in HDL-C levels. In line with this, the AIP value has also decreased. The conclusion was IBTE have affect to improve the blood lipid profile of dyslipidemia rats and the AIP.

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What this paper is about

To evaluate the effect of Ipomea batatas tuber extract (IBTE) on blood lipid profile and atherogenic index in plasma (AIP) of dyslipidemia rats. First, IBTE was extracted by methanol. Fat-rich diets was given for 30 days to induce dyslipidemia in rats. Then, IBTE was given to dyslipidemia rats for 21 days. Lipid profiles in the form of total cholesterol (TC), triglycerides (TG), low density lipoprotein-cholesterol (LDL-C), high lipoprotein-cholesterol (HDL-C) and AIP in rats were measured and analyzed. The results showed that administration of IBTE 150, 300 and 600mg/kg BW was able to improve the blood lipid profile of dyslipidemia rats, where there was a decrease in levels of TC, TG and LDL-C, and an increase in HDL-C levels. In line with this, the AIP value has also decreased. The conclusion was IBTE have affect to improve the blood lipid profile of dyslipidemia rats and the AIP.

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Available abstract

To evaluate the effect of Ipomea batatas tuber extract (IBTE) on blood lipid profile and atherogenic index in plasma (AIP) of dyslipidemia rats. First, IBTE was extracted by methanol. Fat-rich diets was given for 30 days to induce dyslipidemia in rats. Then, IBTE was given to dyslipidemia rats for 21 days. Lipid profiles in the form of total cholesterol (TC), triglycerides (TG), low density lipoprotein-cholesterol (LDL-C), high lipoprotein-cholesterol (HDL-C) and AIP in rats were measured and analyzed. The results showed that administration of IBTE 150, 300 and 600mg/kg BW was able to improve the blood lipid profile of dyslipidemia rats, where there was a decrease in levels of TC, TG and LDL-C, and an increase in HDL-C levels. In line with this, the AIP value has also decreased. The conclusion was IBTE have affect to improve the blood lipid profile of dyslipidemia rats and the AIP.

Key concepts: Dyslipidemia, Lipid profile, Cholesterol, Endocrinology, Internal medicine, Total cholesterol, Chemistry, Lipoprotein

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Analysis of Lipid profile and Atherogenic index (AIP) in dyslipidemia rats given Ipomea batatas tuber extract (IBTE) — Research Paper | ScholarLens