The relationship of bile acid with biochemical tests in the diagnosis of intrahepatic cholestasis of pregnancy

Intrahepatic pregnancy cholestasis (ICP) is associated with increased fetal complications. It is linked to an increased risk. Early diagnosis of this disease reduces these fetal complications. In this study, it was aimed to determine the sensitivity and specificity of biochemical tests according to cut off values. The values of 14 patients with bile acid ≥40 μmol / L diagnosed with intrahepatic cholestasis of pregnancy and 40 patients with bile acid <40 μmol / L were compared retrospectively with 60 control patients. In ICP patients, the ALT and AST values in patients with group 1 with bile acid ≥40 μmol / L and group 2 with bile acid <40 μmol / L were significantly higher than the control group (p = 0.0001 for both markers). Groups 1 and 2 with ICP patients have high sensitivity and specificity compared to the cut off value of ALT and AST. In our study, it was found that increased the risk of preterm delivery in ICP patients. Especially in cases where bile acid was ≥ 40 μmol / L, complications such as preterm delivery and low birth weight increased in proportion to the increase in bile acid. In the ICP patients, AST and especially ALT values increased in proportion to the increase in bile acid.