Clinical significance detecting levels of IL-17,IL-10,TGF-β1 and regulatory T cell in patients with multiple sclerosis

Objective To study the clinical significance of detecting the level of IL-17,IL-10,TGF-β1 and CD4 +CD25 + Foxp3 + T cell in patients with Multiple sclerosis( MS). Methods Detected the levels of serum IL-17 and IL-10 by ELISA in patients with MS and healthy controls and to detect the levels of peripheral blood CD4 + CD25 + Foxp3+ T cell by flow cytometry in patients with MS and healthy controls. Results The levels of serum IL-17 in patients with MS were significantly higher than that of healthy controls and the levels of IL-10,TGF-β1 and CD4 + CD25 +Foxp3 + T cell were significantly lower in the patients with MS than that of healthy controls. Conclusion IL-17,IL-10,TGF-β1 and CD4 + CD25 + Foxp3 + T cell might play important roles in the induction of MS and be helpful in the diagnosis of MS.