2021•Journal of NeurophysiologyOpen access

High-frequency electrical stimulation of cutaneous nociceptors differentially affects pain perception elicited by homotopic and heterotopic electrical stimuli

Emanuel N. van den Broeke, Marta Urdí, André Mouraux, José Biurrun Manresa, Diana Torta

Abstract

High-frequency electrical stimulation (HFS) of cutaneous nociceptors can reduce pain perception to single electrical stimuli delivered through the same electrode. Moreover, single electrical stimuli delivered to the skin next to the site at which HFS was applied are perceived as more intense compared with that at the contralateral control site, indicating the presence of heterosynaptic effects for electrical stimuli.

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Key concepts: Nociceptor, Stimulation, Nociception, Long-term potentiation, Neuroscience, Functional electrical stimulation, Electrophysiology, Chemistry