Distribution of chloramphenicol in blood and milk after oral administration in goat

In goats, single dose oral administration of chloramphenicol did not produce therapeutic blood levels of the drug at 25mg and 50 mg/kg bw but at 100 mg and 200 mg/kg it produced therapeutic antimicrobial levels for 24 h and for more than 24 h, respectively. Single oral dose at 100 mg and 200 mg/kg gave therapeutic milk levels for 3 to 24 h and 1 h to 48 h, respectively. Both blood and milk were free from the drug at 72 h post administration after 100 and 200 mg/kg single oral doses. Species difference with regard to drug adsorptions from G. I. tract has been Suggested.