2021•Journal of Gandhara Medical and Dental ScienceOpen access

P53 Protein Expression in Epithelial Lining of Odontogenic Cysts: An Immunohistochemical Descriptive Case Study

Aqib Sohail, Aneela Amjad, Nighat Zahid, Asad Aizaz Chatha, Nauman Rauf Khan, A. Iqbal, Bilal Yusuf

Abstract

OBJECTIVES: The current study was conducted to analyze immunohistochemical appearance of P53 protein in odontogenic cysts. METHODOLOGY: Thirty paraffin blocks of confirmed case were prepared to investigate the immunohistochemical appearance of P53 protein. RESULTS: Sixteen out of thirty odontogenic cysts (53.3%) showed P53, four out of ten dentigerous cyst (40%) had P53, twelve out of fifteen odontogenic keratocysts (80%) expressed P53 while none of the five radicular cysts (0%) showed P53 protein. CONCLUSION: Reclassification of OKC as keratocystic odontogenic tumor was supported by the present study and its findings.

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Key concepts: Immunohistochemistry, Radicular Cyst, Dentigerous cyst, Odontogenic, P53 protein, Pathology, P53 expression, Medicine