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2021•International Journal of Clinical and Diagnostic PathologyOpen access

Comparative study of significance of serum matrix metalloproteinase-13 (MMP-13) and carbohydrate antigen 15.3 (CA15.3) as an early tumor marker in female patients with breast cancer

Sangeeta Yadav, Rati Mathur, Suresh Singh

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Abstract

Aim: To determine the usefulness of serum Matrix metalloproteinase-13 (MMP-13) along with Carbohydrate Antigen 15.3 (CA15.3) as an early tumor marker in female patients with breast cancer.Method: The breast cancer patients were recruited from OPD/IPD of Surgery and Oncology department of SMS Hospital, and evaluated serum MMP-13 and CA15.3. Total 180 subjects were included in this study.90 breast cancer Patients were divided according to different stages and 90 control subjects also included.Results: Serum MMP-13 and CA15.3 level raised significantly in breast cancer patients. Further increases with the advanced stage of the breast cancer.Conclusion: Both MMP-13 and CA15.3 can be useful diagnostic tumor marker in breast cancer.

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Aim: To determine the usefulness of serum Matrix metalloproteinase-13 (MMP-13) along with Carbohydrate Antigen 15.3 (CA15.3) as an early tumor marker in female patients with breast cancer.Method: The breast cancer patients were recruited from OPD/IPD of Surgery and Oncology department of SMS Hospital, and evaluated serum MMP-13 and CA15.3. Total 180 subjects were included in this study.90 breast cancer Patients were divided according to different stages and 90 control subjects also included.Results: Serum MMP-13 and CA15.3 level raised significantly in breast cancer patients. Further increases with the advanced stage of the breast cancer.Conclusion: Both MMP-13 and CA15.3 can be useful diagnostic tumor marker in breast cancer.

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Available abstract

Aim: To determine the usefulness of serum Matrix metalloproteinase-13 (MMP-13) along with Carbohydrate Antigen 15.3 (CA15.3) as an early tumor marker in female patients with breast cancer.Method: The breast cancer patients were recruited from OPD/IPD of Surgery and Oncology department of SMS Hospital, and evaluated serum MMP-13 and CA15.3. Total 180 subjects were included in this study.90 breast cancer Patients were divided according to different stages and 90 control subjects also included.Results: Serum MMP-13 and CA15.3 level raised significantly in breast cancer patients. Further increases with the advanced stage of the breast cancer.Conclusion: Both MMP-13 and CA15.3 can be useful diagnostic tumor marker in breast cancer.

Key concepts: Breast cancer, Medicine, CA15-3, CA 15-3, Tumor marker, Internal medicine, Oncology, Cancer

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Comparative study of significance of serum matrix metalloproteinase-13 (MMP-13) and carbohydrate antigen 15.3 (CA15.3) as an early tumor marker in female patients with breast cancer — Research Paper | ScholarLens