2014•Ain Shams Journal of SurgeryOpen access

Treatment of infantile hemangioma with propranolol: A review of 25 cases

Mohamed Ramadan, Karam AAllam, Mostafa Hariedy, Ahmed Elsherbiny

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Abstract

Introduction:Hemangiomaisconsideredthemostcommontumorofinfancy Rapidgrowth ofhemangiomaduringitsproliferativephasecan leadtodisfigurementandissometimes associatedwithcomplications.Propranololhasbeenusedrecentlyinthetreatmentforinfantile hemangiomasandhasshownpromisingresults.Wearereportingourinitialexperiencewiththe useofpropranololintreatmentofhemangiomas duringinfancy Patients and methods: Thisstudyisaretrospectiveanalysis ofdataof25patients with cutaneous infantile hemangiomas treated with oral propranolol in the hamangioma and vascularmalformationclinic,SohagCraniofacialUnit,SohagUniversityHospital. Results: Favorableresponsetopropranolol wasobservedinallpatientsintermsofarrest ofgrowth,reductionof sizeand/orfadingofcolorof thelesion.Nosignificantsideeffectswere observednecessitatingstoppingoftreatment. Conclusion:Propranololisaneffective treatment forinfantile hemangioma and should beconsideredasafirstlinetherapy. Alsoitwassafelyusedininfancywithnosignificant complicationsreportedinourseries. MohamedRamadan

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Introduction:Hemangiomaisconsideredthemostcommontumorofinfancy Rapidgrowth ofhemangiomaduringitsproliferativephasecan leadtodisfigurementandissometimes associatedwithcomplications.Propranololhasbeenusedrecentlyinthetreatmentforinfantile hemangiomasandhasshownpromisingresults.Wearereportingourinitialexperiencewiththe useofpropranololintreatmentofhemangiomas duringinfancy Patients and methods: Thisstudyisaretrospectiveanalysis ofdataof25patients with cutaneous infantile hemangiomas treated with oral propranolol in the hamangioma and vascularmalformationclinic,SohagCraniofacialUnit,SohagUniversityHospital. Results: Favorableresponsetopropranolol wasobservedinallpatientsintermsofarrest ofgrowth,reductionof sizeand/orfadingofcolorof thelesion.Nosignificantsideeffectswere observednecessitatingstoppingoftreatment. Conclusion:Propranololisaneffective treatment forinfantile hemangioma and should beconsideredasafirstlinetherapy. Alsoitwassafelyusedininfancywithnosignificant complicationsreportedinourseries. MohamedRamadan

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Available abstract

Introduction:Hemangiomaisconsideredthemostcommontumorofinfancy Rapidgrowth ofhemangiomaduringitsproliferativephasecan leadtodisfigurementandissometimes associatedwithcomplications.Propranololhasbeenusedrecentlyinthetreatmentforinfantile hemangiomasandhasshownpromisingresults.Wearereportingourinitialexperiencewiththe useofpropranololintreatmentofhemangiomas duringinfancy Patients and methods: Thisstudyisaretrospectiveanalysis ofdataof25patients with cutaneous infantile hemangiomas treated with oral propranolol in the hamangioma and vascularmalformationclinic,SohagCraniofacialUnit,SohagUniversityHospital. Results: Favorableresponsetopropranolol wasobservedinallpatientsintermsofarrest ofgrowth,reductionof sizeand/orfadingofcolorof thelesion.Nosignificantsideeffectswere observednecessitatingstoppingoftreatment. Conclusion:Propranololisaneffective treatment forinfantile hemangioma and should beconsideredasafirstlinetherapy. Alsoitwassafelyusedininfancywithnosignificant complicationsreportedinourseries. MohamedRamadan

Key concepts: Propranolol, Infantile hemangioma, Hemangioma, Medicine, Dermatology, Pediatrics, Radiology, Internal medicine

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