Formulation development and stability studies of bilayer tablets of linagliptin and metformin

In vitro release studies were carried out by USP type 2 paddle apparatus. The results showed that Eudragit’s in a sustained layer can control the release of drugs. The in vitro release profile of the drug from the sustained-release layer could be expressed by Higuchi's equation as the pilot shows high linearity R2 =0.9911and diffusion was the dominant mechanism of drug release. The formulation (F6) having an immediate-release layer produces an immediate effect of 93.53 ± 0.30 within 45 minutes followed by a sustained release effect of 94.77 ± 0.37 up to 8 hours. The present study concluded that Bilayer tablets of Lingaptin and Metformin HCl can be a better alternative to conventional dosage forms for providing sustained drug delivery.