THE EFFECT OF ADDITION OF METFORMIN TO CLOMIPHENE CITRATE IN INDUCTION OF OVULATION FOR FEMALES WITH POLYCYSTIC OVARY SYNDROME

Background: Clomiphene citrate is considered first line therapy for ovulation induction for women with polycystic ovary syndrome (PCOS) and infertility the benefits of metformin on insulin sensitivity have been demonstrated in non-diabetic women with PCOS. Objective: Comparing the efficacy of Clomiphene citrate + Metformin, and Clomiphene citrate alone in treatment of anovulation. Patients and Methods: Sixty patients were included in this study and were divided into two equal groups: The first group received (Clomiphene citrate for induction of ovulation starting from day 2 of the cycle for 5 days in a dose of 100 mg/day and Metformin 500mg tablets twice daily; while the second group received only Clomiphene citrate for induction of ovulation starting from day 2 of the cycle for 5 days with a dose of 100mg/day. Results: Both lines of treatment were effective in treatment of PCOS patients without statistically significant difference between Clomiphene citrate +Metformin group, and Clomiphene citrate group as regard ovulation rate. There was a statistically significant decrease in oligomenorrhea after treatment in comparison to their values before treatment in both groups. Conclusion: Both CC+Metformin, and CC alone were effective in treatment of infertility in PCOS patients.