ScholarLens Back to search
1994•Zagazig Journal of Pharmaceutical Sciences/Zagazig Journal of Pharmaceutical ScienceOpen access

STRUCTURE-ACTIVITY INVESTIGATION OF ATYPICAL ACRIDINE DERIVATIVES AS ANTIMICROBIAL AGENTS

Mohamed Al-Ashmawi, Mohamed El‐Sadek, Mohamed El-Bermawy, Ashraf A. Kadry, Osama Al-Sabbagh

Open full text 1 citations

Abstract

Although acridines and many tricylic compounds are known to possess potent antimicrobial activity, yet most of these compounds are either toxic (cannot be used systemically) or have other pharmacological activities. To develop safe and effective agents, we report the design and synthesis of nonclassical acridine derivatives. Biological evaluation of these acridine analogues showed a consistent structure-activity relationship. Some of these acridines showed potent antimicrobial activity, compound 22 exhibited MIC of 7 ug / mL.

Open-access reader

About this research paper

What this paper is about

Although acridines and many tricylic compounds are known to possess potent antimicrobial activity, yet most of these compounds are either toxic (cannot be used systemically) or have other pharmacological activities. To develop safe and effective agents, we report the design and synthesis of nonclassical acridine derivatives. Biological evaluation of these acridine analogues showed a consistent structure-activity relationship. Some of these acridines showed potent antimicrobial activity, compound 22 exhibited MIC of 7 ug / mL.

Why it matters

OpenAlex reports 1 citations for this work. Citation counts describe recorded attention and do not establish research quality.

Key contribution

A contribution statement is not available in the OpenAlex record.

Method / approach

Method details are not available in the OpenAlex metadata.

Main findings

Findings are not separately available in the OpenAlex metadata.

Limitations

Limitations are not available in the OpenAlex metadata.

Applications

Application details are not available in the OpenAlex metadata.

Available abstract

Although acridines and many tricylic compounds are known to possess potent antimicrobial activity, yet most of these compounds are either toxic (cannot be used systemically) or have other pharmacological activities. To develop safe and effective agents, we report the design and synthesis of nonclassical acridine derivatives. Biological evaluation of these acridine analogues showed a consistent structure-activity relationship. Some of these acridines showed potent antimicrobial activity, compound 22 exhibited MIC of 7 ug / mL.

Key concepts: Acridine, Antimicrobial, Acridine derivatives, Chemistry, Combinatorial chemistry, Structure–activity relationship, Biological activity, Stereochemistry

Related papers

Related paper 1Related paper 2Related paper 3
Back to paper searchBrowse research topicsOriginal source
STRUCTURE-ACTIVITY INVESTIGATION OF ATYPICAL ACRIDINE DERIVATIVES AS ANTIMICROBIAL AGENTS — Research Paper | ScholarLens