STABILITY INDICATING ASSAY METHOD BY FIRST ORDER DERIVATIVE SPECTROPHOTOMETRIC DETERMINATION OF TELMISARTAN IN BULK AND PHARMACEUTICAL FORMULATION

Background: In present investigation, Stability Indicating assay method by UV first derivative spectrophotometric methods has been developed for the determination of Telmisartan in pharmaceutical formulation. The solutions of standard and sample were prepared in 0.1 N sodium hydroxide. Method: In the UV spectrophotometric method, the first order derivative spectrophotometric method was followed. Results and Discussion: In the UV spectrophotometric method, for the first order derivative spectrophotometric method, the drug was determined at 325 nm with the linearity ranges 4-24 μg/ml. The linear regression equation is Y = 0.002x +0.001, with regression coefficient, R 2 = 1. The calibration graphs constructed at their wavelength of determination were found to be linear derivative spectrophotometric methods. The proposed methods have been extensively validated. Conclusion: There was no significant difference between the performance of the proposed method regarding the mean values and standard deviations. The described method can be readily utilized for analysis of pharmaceutical formulation.