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2021•Technology in Cancer Research & TreatmentOpen access

Hypoxia and the Tumor Microenvironment

Yue Li, Long Zhao, Xiao-Feng Li

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Abstract

Hypoxia is an important feature of the tumor microenvironment, and is closely associated with cell proliferation, angiogenesis, metabolism and the tumor immune response. All these factors can further promote tumor progression, increase tumor aggressiveness, enhance tumor metastatic potential and lead to poor prognosis. In this review, these effects of hypoxia on tumor biology will be discussed, along with their significance for tumor detection and treatment.

About this research paper

What this paper is about

Hypoxia is an important feature of the tumor microenvironment, and is closely associated with cell proliferation, angiogenesis, metabolism and the tumor immune response. All these factors can further promote tumor progression, increase tumor aggressiveness, enhance tumor metastatic potential and lead to poor prognosis. In this review, these effects of hypoxia on tumor biology will be discussed, along with their significance for tumor detection and treatment.

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OpenAlex reports 405 citations for this work. Citation counts describe recorded attention and do not establish research quality.

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Available abstract

Hypoxia is an important feature of the tumor microenvironment, and is closely associated with cell proliferation, angiogenesis, metabolism and the tumor immune response. All these factors can further promote tumor progression, increase tumor aggressiveness, enhance tumor metastatic potential and lead to poor prognosis. In this review, these effects of hypoxia on tumor biology will be discussed, along with their significance for tumor detection and treatment.

Key concepts: Tumor microenvironment, Hypoxia (environmental), Angiogenesis, Tumor hypoxia, Cancer research, Immune system, Tumor progression, Tumor cells

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